Endocrine Abstracts

Background: Carcinoid crisis (CC) may rarely occur as a complication of general anesthesia/surgery or peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumor (NET). The incidence of CC as a complication of PRRT is underestimated and comes to 10% of all radioisotope therapies. Progressive organ dysfunction, decrease or increase in blood pressure SBP <80 mmHg or >180 mmHg, unexplained tachyarrhythmia with heart rate >120/ min, bronchoconstr...

Diagnostic procedures reveal that majority of incidentally found adrenal tumours (adrenal incidentalomas, AI) appear to be benign adenomas. However, AI accompanying malignant tumours must be diagnosed very carefully to take a proper decision concerning their management. In the registry of the Department of Endocrinology in Warsaw, there are 1888 patients (1388 women, 500 men, F/M ratio 2.8) with AI, 10–87 years old. Primary malignant tumours were diagnosed in 155 patients...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as developmental failure of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism. In contrast, subjects presenting TH were only sporadically involved. In addition, whether the same factors are responsible for development of TH and other forms of thyroid dysgenesis is still to be elucidated. Recent stud...

Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as failure of the development of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism; in contrast, subjects presenting TH were only sporadically involved. Changes in transcription factor genes, including TTF1, TTF2 and PAX8, which play an important role in thyroid embryogenesis, have been postu...

Introduction: The question of whether pregnancy has any impact on the prognosis of differentiated thyroid cancer diagnosed in pregnant women was addressed mainly in retrospective analyses, which showed no significant differences in overall and progression-free survival between women diagnosed during pregnancy in comparison to women whose thyroid cancer diagnosis was unrelated to pregnancy. Thus, following the recent guidelines, watchful waiting is the preferred option, and sur...

Introduction: An increase in the incidence of differentiated thyroid cancer (DTC) has been observed in recent decades. Despite the excellent prognosis, DTC patients remain on lifelong oncologic follow-up after treatment, due to fear of recurrence.Aim: Was to evaluate the frequency of real recurrence, defined as appearance of structural or biochemical disease after >12 month period of no evidence of disease (NED) in DTC patients.<p class="abstext"...

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves’ orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves’ disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent th...

Introduction: In years 1996–2000, the predominance of papillary thyroid carcinoma (PTC) (70.3%) compared to follicular thyroid carcinoma (FTC; 27.0%) and medullary thyroid carcinoma (MTC; 2.7%) was observed in our region. AIT coexisted in 1 PTC (2.7% of all cancers and 3.8% in PTC group).Aim: The aim of retrospective study was to analyze the coexistence of AIT and TC in years 2001-2015 in relation to years 1996–2000.Mater...

Introduction: Some studies suggest that thyroid autoimmunity might be associated with increased cardiovascular-risk. However, the exact pathophysiology of this relationship has not yet been fully understood. In this study we aimed to analyze the influence of the levothyroixine (L-T4) replacement therapy and of anti-thyroperoxidase antibodies (TPOAbs) on homocysteine (Hcy) levels in patients with thyroid autoimmune disease.Method...

Introduction: Ghrelin - a growth hormone (GH) secretagogue - presents a circadian rhythm with higher nocturnal concentration (similar to GH). As daily ghrelin production depended on food intake and nutritional state, we decided to assess ghrelin concentration at 60th at 90th minute after falling asleep and at 6:00 am (after 12 hours of fasting), and compare the results to determine the differences between nocturnal and morning ghrelin release in short children, both with idiop...